Dichloromethane → 2-Chloro-N-pyridin-2-yl-acetamide

HRID 354640

反応式

HRID 354640 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=1.C(Cl)Cl.[Cl:11][CH2:12][C:13](Cl)=[O:14]>O>[N:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[NH:1][C:13](=[O:14])[CH2:12][Cl:11]

参加物

5

反応物 3

HCID 6344DichloromethaneHCID 6577Chloroacetyl chlorideHCID 104392-Aminopyridine

生成物 1

HCID 2894352-Chloro-N-pyridin-2-yl-acetamide

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To a solution of 9.42 g. (0.1 mole) of 2-aminopyridine in 50 ml. of methylene chloride was added dropwise 4.0 ml. (0.05 mole) of chloroacetyl chloride in 20 ml. of the same solvent, keeping the reaction temperature at -20° to -10° C. for one hour. After stirring at room temperature for 10 hours, 50 ml. of water was added and the organic layer separated. The organic solution was washed with water and a brine solution and was dried over magnesium sulfate. Removal of the solvent in vacuo gave 6.64 g. (78%), m.p. 114°-117° C., of the desired product.

後処理

  1. customat -20° to -10° C.
  2. customfor one hour
  3. customthe organic layer separated
  4. washThe organic solution was washed with water
  5. dry with materiala brine solution and was dried over magnesium sulfate
  6. customRemoval of the solvent in vacuo
  7. customgave 6.64 g

出典と根拠

ORDレコード
ord-c8118f53ef5d431aaa4f72d8f69651ac
出典データセット
uspto-grants-1983_03
特許番号
US04376204

関連ノート

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