Chloride → 17beta-Benzoyloxy-5alpha-androstan-4-one

HRID 354915ノート

反応式

HRID 354915 の反応式
[C:1](Cl)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH:10][C@H:11]1[CH2:16][CH2:15][C@H:14]2[C@H:17]3[C@H:27]([CH2:28][CH2:29][C@:12]12[CH3:13])[C@:25]1([CH3:26])[C@H:20]([C:21](=[O:30])[CH2:22][CH2:23][CH2:24]1)[CH2:19][CH2:18]3.[Cl-]>N1C=CC=CC=1>[C:1]([O:10][C@H:11]1[CH2:16][CH2:15][C@H:14]2[C@H:17]3[C@H:27]([CH2:28][CH2:29][C@:12]12[CH3:13])[C@:25]1([CH3:26])[C@H:20]([C:21](=[O:30])[CH2:22][CH2:23][CH2:24]1)[CH2:19][CH2:18]3)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 312ChlorideHCID 7412Benzoyl chlorideHCID 15341898HCID 15341898、化合物

生成物 1

HCID 1534189917beta-Benzoyloxy-5alpha-androstan-4-one

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

To 12 ml of dry pyridine and 6 ml of benzoyl chloride is added 2.0 g of the product of Step F to form a solution which is heated on a steam bath for 30 min. and then poured into 175 ml of ice water and stirred to decompose the excess chloride. The reaction mixture is filtered, washed with water, and pumped dry under high vacuum at 50° C. to yield 1.7 g of final product.

後処理

  1. customto form a solution which
  2. temperatureis heated on a steam bath for 30 min.
  3. filtrationThe reaction mixture is filtered
  4. washwashed with water
  5. custompumped dry under high vacuum at 50° C.

出典と根拠

ORDレコード
ord-20eaecd6abc74531a2c2484020935134
出典データセット
uspto-grants-1983_03
特許番号
US04377584

反応ノート

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