Acetic Acid → 3-Hydroxy-2-phenyl-6-azabenzo[b]thiophene
反応式
[C:1]1([CH2:7][C:8]2[CH:9]=[N:10][CH:11]=[CH:12][C:13]=2[C:14](OC)=[S:15])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[H-].[Na+].C(O)(=[O:22])C>O1CCCC1.CN(C)C=O>[OH:22][C:8]1[C:13]2[CH:12]=[CH:11][N:10]=[CH:9][C:14]=2[S:15][C:7]=1[C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1参加物
6
反応条件
- 温度
- 60 °C
実験手順
A solution of 4.8 g (19 mmol) of methyl 3-phenylmethylthiopyridine-4-carboxylate in 10 mL of tetrahydrofuran was added to a slurry of 2.40 g (60 mmol) of 60% sodium hydride in 10 mL of N,N-dimethylformamide and the resulting mixture was stirred at 60° C. for 3 hours. The solution was poured onto ice water and acidified with glacial acetic acid. The filtrate was collected to afford 1.6 g (38%) of white solid.
後処理
- additionThe solution was poured onto ice water
- customThe filtrate was collected
出典と根拠
- ORDレコード
- ord-5c9fce38eb274a838188106b5d0e387b
- 出典データセット
- uspto-grants-1988_08
- 特許番号
- US04767766
反応ノート
読み込み中…