1-Chloro-4-(trifluoromethyl)benzene → 4-(4-Trifluoromethylphenyl)morpholine

HRID 355561

反応式

HRID 355561 の反応式
Cl[C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][CH:3]=1.[NH:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1.CC(C)([O-])C.[K+].[Br-].[Li+]>C1(C)C=CC=CC=1>[F:9][C:8]([F:11])([F:10])[C:5]1[CH:6]=[CH:7][C:2]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)=[CH:3][CH:4]=1.[F:9][C:8]([F:11])([F:10])[C:5]1[CH:4]=[C:3]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[CH:2]=[CH:7][CH:6]=1

参加物

7

反応物 4

HCID 73941-Chloro-4-(trifluoromethyl)benzeneHCID 8083MorpholineHCID 82050Lithium BromideHCID 23665647Potassium tert-butoxide

生成物 2

HCID 109333104-(4-Trifluoromethylphenyl)morpholineHCID 154202994-(3-(Trifluoromethyl)phenyl)morpholine

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

2.0 mmol of 4-chlorobenzotrifluoride, 2.4 mmol of morpholine, 2.8 mmol of potassium tert-butoxide, 0.4 mmol of lithium bromide, 1.0 mol-% (9.4 mg) of palladacycle (trans-di(μ-aceto)-bis[o[di-o-tolylphosphino)benzyl]dipalladium(II) in 10 ml of toluene are reacted according to the GWI to give 4-trifluoromethylphenylmorpholine and 3-trifluoromethylphenylmorpholine in the ratio 5:1 in 62% yield.

出典と根拠

ORDレコード
ord-2218640268a64655b55ace309eaf0f6d
出典データセット
uspto-grants-1998_11
特許番号
US05831128

関連ノート

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