Benzyl Bromide → HCID 70184287、化合物

Cis-2-Butene-1,4 diol (10 g, 0.113 mol) was dissolved in THF (50 mL) and added to a slurry containing THF (100 mL) and NaH (5.9 g, 0.246 mol, 60% dispersion). The mixture was stirred 15 minutes then benzyl bromide (14.8 mL, 0.124 mole) was added and the mixture was stirred 1.5 hours at room temperature then refluxed 3 hours and finally cooled to room temperature. The reaction mixture was quenched with 20 mL water and concentrated in vacuo to an orange oil. The oil was dissolved in ethyl acetate (100 mL), washed with 10% NaCl (50 mL), dried over anhydrous sodium sulfate, filtered and concentrated in vacuo to afford 15 g of the title compound as a yellow oil.

1. additionadded to a slurry
2. stirringthe mixture was stirred 1.5 hours at room temperature
3. temperaturethen refluxed 3 hours
4. customThe reaction mixture was quenched with 20 mL water
5. concentrationconcentrated in vacuo to an orange oil
6. dissolutionThe oil was dissolved in ethyl acetate (100 mL)
7. washwashed with 10% NaCl (50 mL)
8. dry with materialdried over anhydrous sodium sulfate
9. filtrationfiltered
10. concentrationconcentrated in vacuo

ORDレコード

ord-b7b687f14bea4493bdd05376f98cb498

出典データセット

uspto-grants-1998_11

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US05831115