Sodium Hydroxide → 6-Chloro-5-methylindoline
反応式
[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[CH:7][NH:8]2)=[CH:4][C:3]=1[CH3:11].C([BH3-])#N.[Na+].[OH-].[Na+]>C(O)(=O)C.O>[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][CH2:7][NH:8]2)=[CH:4][C:3]=1[CH3:11]参加物
6
反応条件
- 温度
- 15 °C
実験手順
6-Chloro-5-methylindole (D9) (0.109 g, 0.66 mmol) was stirred at 15° C. in glacial acetic acid (3 ml), and sodium cyanoborohydride (0.125 g, 1.98 mmol) was added. The mixture was stirred at 15° C. for 2 h, diluted with water (40 ml), basified with solid NaOH, and extracted with ether. The extract was dried (Na2SO4) and evaporated to give the title compound (0.105 g, 95%) as a light yellow solid.
後処理
- extractionextracted with ether
- dry with materialThe extract was dried (Na2SO4)
- customevaporated
出典と根拠
- ORDレコード
- ord-98567b1f3638426da8000ac349344795
- 出典データセット
- uspto-grants-1998_11
- 特許番号
- US05834494
反応ノート
読み込み中…