Hydrazinecarboxaldehyde → 5,6-Dihydro-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine
反応式
[NH:1]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[NH:5][CH2:4][CH2:3][C:2]1=S.[CH:13]([NH:15][NH2:16])=O>C(O)CCC>[CH:13]1[N:1]2[C:7]3[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=3[NH:5][CH2:4][CH2:3][C:2]2=[N:16][N:15]=1参加物
4
実験手順
A mixture of 2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-thione (0.8 g) and 0.80 g of N-formylhydrazine in 8 ml of n-butanol is stirred and refluxed for 18 hours and the solvent removed under vacuum. Ice water is added to the residual solid and the mixture filtered to give 0.312 g of a gray solid, m.p. 162°-165° C.
後処理
- temperaturerefluxed for 18 hours
- customthe solvent removed under vacuum
- additionIce water is added to the residual solid
- filtrationthe mixture filtered
出典と根拠
- ORDレコード
- ord-b10c8b2565b240a1a2712a304e908573
- 出典データセット
- uspto-grants-1998_03
- 特許番号
- US05733905
反応ノート
読み込み中…