Methyl 3-bromothiophene-2-carboxylate → 3-Bromothiophene-2-carboxylic acid

HRID 357739

反応式

HRID 357739 の反応式
C[O:2][C:3]([C:5]1[S:6][CH:7]=[CH:8][C:9]=1[Br:10])=[O:4]>CO.O1CCCC1.[OH-].[Na+]>[Br:10][C:9]1[CH:8]=[CH:7][S:6][C:5]=1[C:3]([OH:4])=[O:2]

参加物

5

反応物 1

HCID 2740074Methyl 3-bromothiophene-2-carboxylate

生成物 1

HCID 27396883-Bromothiophene-2-carboxylic acid収率 97.3%

試薬・触媒・溶媒 3

HCID 887Methanol溶媒HCID 8028Tetrahydrofuran溶媒HCID 14798Sodium Hydroxide溶媒

実験手順

3-Bromo-2-thiophenecarboxylic acid methyl ester (7.74 g) was dissolved in a mixture of methanol (35 ml) and tetrahydrofuran (35 ml), and 1N aqueous sodium hydroxide (53 ml) was added. The mixture was stirred at room temperature for 2 hours and washed with diethyl ether. The aqueous layer was acidified with 1N hydrochloric acid and extracted with ethyl acetate. The extract was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to give 3-bromo-2-thiophenecarboxylic acid (7.05 g) as crystals.

後処理

  1. additionwas added
  2. washwashed with diethyl ether
  3. extractionextracted with ethyl acetate
  4. dry with materialThe extract was dried over anhydrous magnesium sulfate
  5. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-2e768a02cf3442ff911f2d68e5377a5c
出典データセット
uspto-grants-1998_11
特許番号
US05840917

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