Ethyl Acetoacetate → HCID 54710578、化合物

HRID 357834ノート

反応式

HRID 357834 の反応式
[C:1](OCC)(=[O:6])[CH2:2][C:3]([CH3:5])=[O:4].[H-].[Na+].C([Li])CCC.[C:17]([C:25]1[CH:30]=[CH:29][N:28]=[CH:27][CH:26]=1)(=[O:24])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>CCCCCC.C(O)(=O)C.O1CCCC1>[OH:4][C:3]1[CH2:5][C:17]([C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)([C:25]2[CH:26]=[CH:27][N:28]=[CH:29][CH:30]=2)[O:24][C:1](=[O:6])[CH:2]=1

参加物

8

反応物 4

HCID 8868Ethyl AcetoacetateHCID 24758Sodium hydrideHCID 267314-BenzoylpyridineHCID 178418339Butyllithium

生成物 1

HCID 54710578HCID 54710578、化合物

試薬・触媒・溶媒 3

HCID 176Acetic Acid溶媒HCID 8028Tetrahydrofuran溶媒HCID 8058Hexane溶媒

実験手順

The title compound was prepared as described in General Method 1 using 90 mmol of ethyl acetoacetate, 99 mmol of NaH 60% dispersion in oil, 95 mmol of 1.6M n-butyl lithium in hexane and 90 mmol of 4-benzoylpyridine and 250 mL of tetrahydrofuran. The reaction mixture was acidified with acetic acid and the crude solid was washed with ice water (m.p. 148°-150° C).

後処理

  1. washthe crude solid was washed with ice water (m.p. 148°-150° C)

出典と根拠

ORDレコード
ord-8d8abd42ff4b40b8be27ffad3d770348
出典データセット
uspto-grants-1998_11
特許番号
US05840751

反応ノート

読み込み中…