Butylamine → HCID 20064775、化合物

HRID 359289ノート

反応式

HRID 359289 の反応式
[CH2:1]([NH2:5])[CH2:2][CH2:3][CH3:4].Cl[C:7]1[S:8][C:9]([C:16]([O:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[O:17])=[C:10]([C:12]([F:15])([F:14])[F:13])[N:11]=1>C(#N)C>[CH2:1]([NH:5][C:7]1[S:8][C:9]([C:16]([O:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[O:17])=[C:10]([C:12]([F:14])([F:13])[F:15])[N:11]=1)[CH2:2][CH2:3][CH3:4]

参加物

4

反応物 2

HCID 8007ButylamineHCID 91715Flurazole

生成物 1

HCID 20064775HCID 20064775、化合物収率 36.3%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

By the procedure of Example 39, a stirred mixture of 20 ml acetonitrile, 3.65 g (49.8 mmol) of n-butylamine, and 8 g (24.9 mmol) of benzyl 2-chloro-4-trifluoromethyl-5-thiazolecarboxylate (prepared as described in U.S. Pat. No. 4,199,506), was heated at reflux for 24 hours. The product was separated and then recrystallized from hexane to yield 3.24 g of a yellow solid product (m.p.=77°-79° C.) identified in Table I.

後処理

  1. customprepared
  2. temperature4,199,506), was heated
  3. temperatureat reflux for 24 hours
  4. customThe product was separated
  5. customrecrystallized from hexane

出典と根拠

ORDレコード
ord-002139dbeb3b46189b28db252281427e
出典データセット
uspto-grants-1991_03
特許番号
US05000775

反応ノート

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