Isopropylamine → Ethyl 2-(isopropylamino)-4-(trifluoromethyl)thiazole-5-carboxylate
反応式
[CH:1]([NH2:4])([CH3:3])[CH3:2].Cl[C:6]1[S:7][C:8]([C:15]([O:17][CH2:18][CH3:19])=[O:16])=[C:9]([C:11]([F:14])([F:13])[F:12])[N:10]=1>C(#N)C>[CH3:2][CH:1]([NH:4][C:6]1[S:7][C:8]([C:15]([O:17][CH2:18][CH3:19])=[O:16])=[C:9]([C:11]([F:13])([F:12])[F:14])[N:10]=1)[CH3:3]参加物
4
実験手順
By the procedure of Example 39, a stirred mixture of 10 ml acetonitrile, 2.28 g (38.6 mmol) of iso-propylamine, and 5 g (19.3 mmol) of ethyl 2-chloro-4-trifluoromethyl-5-thiazolecarboxylate (prepared as described in U.S. Pat. No. 4,199,506), was heated at reflux for 16 hours. The product was separated and then recrystallized in hexane to yield 2.30 g of a beige solid product (m.p.=94°-97° C.) identified in Table 1.
後処理
- customprepared
- temperature4,199,506), was heated
- temperatureat reflux for 16 hours
- customThe product was separated
- customrecrystallized in hexane
出典と根拠
- ORDレコード
- ord-0029207d60cf4c5d934520548cd0e229
- 出典データセット
- uspto-grants-1991_03
- 特許番号
- US05000775
反応ノート
読み込み中…