反応式
F[C:2]1[C:15]([F:16])=[C:14]([F:17])[C:13]([F:18])=[C:12]([F:19])[C:3]=1[CH:4]=[C:5]1[S:9]C(=S)N[C:6]1=[O:11].[OH-:20].[Na+].Cl>O>[F:19][C:12]1[C:3]2[CH:4]=[C:5]([C:6]([OH:20])=[O:11])[S:9][C:2]=2[C:15]([F:16])=[C:14]([F:17])[C:13]=1[F:18]参加物
5
反応条件
- 温度
- 90 °C
実験手順
78 g of 2,3,4,5,6-pentafluorobenzylidene rhodanine were added in small portions to a stirred solution of 68 g of NaOH in 300 ml of water. The resultant clear red solution was heated to 90° C. for one hour, cooled in ice, acidified with concentrated HCl, and the cream coloured solid which was produced was filtered and washed. The crude product (59 g) was purified by sublimation to give 4,5,6,7-tetrafluorobenzothiophen-2-carboxylic acid having a melting point of 200° C.
後処理
- temperaturecooled in ice
- customwas produced
- filtrationwas filtered
- washwashed
- customThe crude product (59 g) was purified by sublimation
出典と根拠
- ORDレコード
- ord-6cf3f054d9ff4d0bb059e798eeecbbd0
- 出典データセット
- uspto-grants-1991_03
- 特許番号
- US05001163
関連ノート
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