Cetyl Alcohol → 8-(Hexadecyloxy)-7-methoxy-1-octene

HRID 35957

反応式

HRID 35957 の反応式
[H-].[Na+].[OH:3][CH2:4][CH:5]([O:12][CH3:13])[CH2:6][CH2:7][CH2:8][CH2:9][CH:10]=[CH2:11].S(C1C=CC(C)=CC=1)([O-])(=O)=O.[CH2:25](O)[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH3:40]>CN(C)C=O.O>[CH2:40]([O:3][CH2:4][CH:5]([O:12][CH3:13])[CH2:6][CH2:7][CH2:8][CH2:9][CH:10]=[CH2:11])[CH2:39][CH2:38][CH2:37][CH2:36][CH2:35][CH2:34][CH2:33][CH2:32][CH2:31][CH2:30][CH2:29][CH2:28][CH2:27][CH2:26][CH3:25]

参加物

7

反応物 4

HCID 2682Cetyl AlcoholHCID 24758Sodium hydrideHCID 85570p-ToluenesulfonateHCID 199395708-Hydroxy-7-methoxy-1-octene

生成物 1

HCID 199395658-(Hexadecyloxy)-7-methoxy-1-octene

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6228Dimethylformamide溶媒2 回

実験手順

To a suspension of 7.4 g of 60% sodium hydride in 100 ml of dimethylformamide was added a solution of 8-hydroxy-7-methoxy-1-octene in 150 ml of dimethylformamide over 1.5 hours. A 63.4 g portion of the tosylate of 1-hexadecanol was added and the mixture was stirred for 18 hours, poured into water and extracted with ether. The ether solution was dried and evaporated. The residue was purified by chromatography giving 41.5 g of the title compound as a oil.

後処理

  1. extractionextracted with ether
  2. dry with materialThe ether solution was dried
  3. customevaporated
  4. customThe residue was purified by chromatography

出典と根拠

ORDレコード
ord-95f61b892d9b4419a2ca820c0f9db754
出典データセット
uspto-grants-1995_05
特許番号
US05411983

関連ノート

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