Ethanolamine → N-(2-hydroxyethyl)nicotinamide

HRID 359874

反応式

HRID 359874 の反応式
[C:1]([O:9]CC)(=O)[C:2]1[CH:7]=[CH:6][CH:5]=[N:4][CH:3]=1.[CH2:12]([CH2:14][NH2:15])[OH:13]>>[OH:13][CH2:12][CH2:14][NH:15][C:1]([C:2]1[CH:3]=[N:4][CH:5]=[CH:6][CH:7]=1)=[O:9]

参加物

3

反応物 2

HCID 700EthanolamineHCID 69188Ethyl Nicotinate

生成物 1

HCID 72663N-(2-hydroxyethyl)nicotinamide収率 85.1%

実験手順

A solution of 49.2 g (0.32525 mol) ethyl nicotinate and 72 g (1.17 mol) ethanolamine was heated at 70° C. for 60 hours. The excess ethanolamine was removed under reduced pressure and the resulting viscous cream oil was stirred with ether for 48 hours. The resulting white solid was removed by filtration, affording 46 g (85.1%) of the title compound melting at 75°-78° C.

後処理

  1. customThe excess ethanolamine was removed under reduced pressure
  2. customThe resulting white solid was removed by filtration

出典と根拠

ORDレコード
ord-d75f9f418ccc4c9a9128f3b7711a460b
出典データセット
uspto-grants-1991_03
特許番号
US05002935

関連ノート

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