Water → (4-Bromobenzylidene)(1-isopropyl-2-methylpropyl)amine

HRID 36029

反応式

HRID 36029 の反応式
[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=O)=[CH:4][CH:3]=1.[CH3:10][CH:11]([CH:13]([NH2:17])[CH:14]([CH3:16])[CH3:15])[CH3:12].O>C1(C)C=CC=CC=1.C1(C)C=CC(S(O)(=O)=O)=CC=1>[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[N:17][CH:13]([CH:14]([CH3:16])[CH3:15])[CH:11]([CH3:12])[CH3:10])=[CH:4][CH:3]=1

参加物

6

反応物 3

HCID 962WaterHCID 707414-BromobenzaldehydeHCID 777023-Pentanamine, 2,4-dimethyl-

生成物 1

HCID 15225580(4-Bromobenzylidene)(1-isopropyl-2-methylpropyl)amine収率 94.9%

試薬・触媒・溶媒 2

HCID 6101p-Toluenesulfonic acid触媒HCID 1140Toluene溶媒

実験手順

A mixture of 4-bromobenzaldehyde (7.3 g, 40.0 mmol), 2,4-dimethylpent-3-ylamine (4.8 g, 41.4 mmol), and para-toluenesulfonic acid (0.05 g, 0.29 mmol) in 125 mL of toluene was heated under reflux while water was removed with a Dean-Stark trap. The toluene then was removed under vacuum and distillation of the remaining residue gave (4-bromobenzylidene)(1-isopropyl-2-methylpropyl)amine (10.71 g) as a clear colorless oil.

後処理

  1. temperaturewas heated
  2. customwas removed with a Dean-Stark trap
  3. customThe toluene then was removed under vacuum and distillation of the remaining residue

出典と根拠

ORDレコード
ord-f7fd81c0bba0492f89d5ca0e44113a33
出典データセット
uspto-grants-1995_05
特許番号
US05412102

関連ノート

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