Water → N-(10,11-Dihydroxyundecyl)phthalimide

HRID 361476

反応式

HRID 361476 の反応式
[CH2:1]([N:12]1[C:16](=[O:17])[C:15]2=[CH:18][CH:19]=[CH:20][CH:21]=[C:14]2[C:13]1=[O:22])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH:10]=[CH2:11].C[N+]1([O-])CC[O:27]CC1.[OH2:31].S([O-])([O-])=O.[Na+].[Na+]>CC(C)=O.O>[OH:31][CH:10]([CH2:11][OH:27])[CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][CH2:1][N:12]1[C:16](=[O:17])[C:15]2=[CH:18][CH:19]=[CH:20][CH:21]=[C:14]2[C:13]1=[O:22]

参加物

6

反応物 4

HCID 962WaterHCID 24437Sodium SulfiteHCID 82029Methyl morpholine oxideHCID 220445222-(Undec-10-en-1-yl)-1H-isoindole-1,3(2H)-dione

生成物 1

HCID 12988906N-(10,11-Dihydroxyundecyl)phthalimide収率 71%

試薬・触媒・溶媒 1

HCID 18366337Propan-2-one--water (1/1)溶媒

実験手順

A solution of N-(10-Undecenyl)phthalimide (4.97 g, 16.6 mmol), prepared as discribed above, 4-methylmorpholine-N-oxide (8.62 mL, 60% by wt in water, 50.0 mmol) and potassium osmate dihydrate (58 mg, 0.16 mmol) in 100 mL acetone/water (1:1 by wt) was stirred for 16 hours. Water (100 mL) and sodium sulfite (10 g) were added and the resulting solution stirred for an additional hour. The resulting reaction mixture was extracted with dichloromethane (3×80 mL) and the organic phase dried using magnesium sulfate and evaporated to obtain 3.93 g (71% yield) of N-(10,11-Dihydroxyundecyl)phthalimide (inventive compound no. 1108).

後処理

  1. stirringthe resulting solution stirred for an additional hour
  2. customThe resulting reaction mixture
  3. extractionwas extracted with dichloromethane (3×80 mL)
  4. customthe organic phase dried
  5. customevaporated

出典と根拠

ORDレコード
ord-f72a386d50494ecc856b4636ca1533b3
出典データセット
uspto-grants-1999_02
特許番号
US05866576

関連ノート

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