Ethyl benzoylacetate → N-(6-methoxybenzothiazol-2-yl)-3-oxo-3-phenylpropanamide

HRID 36161

反応式

HRID 36161 の反応式
CCO[C:4]([CH2:6][C:7]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:8])=[O:5].[NH2:15][C:16]1[S:17][C:18]2[CH:24]=[C:23]([O:25][CH3:26])[CH:22]=[CH:21][C:19]=2[N:20]=1>CC(C)=O>[CH3:26][O:25][C:23]1[CH:22]=[CH:21][C:19]2[N:20]=[C:16]([NH:15][C:4](=[O:5])[CH2:6][C:7](=[O:8])[C:9]3[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=3)[S:17][C:18]=2[CH:24]=1

参加物

4

反応物 2

HCID 7170Ethyl benzoylacetateHCID 156302-Amino-6-methoxybenzothiazole

生成物 1

HCID 19975336N-(6-methoxybenzothiazol-2-yl)-3-oxo-3-phenylpropanamide

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

Ethyl benzoyl acetate (9.5 ml) and 2-amino-6-methoxy benzothiazole (9.01 g) are heated to 140° under house vacuum for 2 hours. After cooling, the residue is taken up in acetone and filtered. The precipitate is dissolved in hot DMF to give an amide, N-(6-methoxybenzothiazol -2-yl)-3-oxo-3-phenylpropanamide (II).

後処理

  1. temperatureAfter cooling
  2. filtrationfiltered
  3. dissolutionThe precipitate is dissolved in hot DMF

出典と根拠

ORDレコード
ord-05a90fbe55264688b82f73bcc6384ff0
出典データセット
uspto-grants-1995_05
特許番号
US05412141

関連ノート

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