Acetaminophen → 4'-Allyloxyacetanilide
反応式
[C:1]([NH:4][C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[CH:7][CH:6]=1)(=[O:3])[CH3:2].[CH2:12](Br)[CH:13]=[CH2:14].C(=O)([O-])[O-].[K+].[K+]>CC(=O)CC>[C:1]([NH:4][C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:14][CH:13]=[CH2:12])=[CH:7][CH:6]=1)(=[O:3])[CH3:2]参加物
5
実験手順
Commercially available 4-acetamido phenol (1 molar equivalent), allyl bromide (1 molar equivalent) and potassium carbonate (1 molar equivalent) in butan-2-one were heated at reflux for 18 hours with stirring. The mixture was cooled, filtered and the solid residue washed with ether. The combined filtrates were evaporated and the solid residue was further purified by crystallisation from ethyl acetate-hexane to give 4-acetamido-1-allyloxy benzene as a colourless solid, m.p. 85°-86° C.
後処理
- temperatureat reflux for 18 hours
- temperatureThe mixture was cooled
- filtrationfiltered
- washthe solid residue washed with ether
- customThe combined filtrates were evaporated
- customthe solid residue was further purified by crystallisation from ethyl acetate-hexane
出典と根拠
- ORDレコード
- ord-00d330a9d291460891b62d2b6f79ce4c
- 出典データセット
- uspto-grants-1999_02
- 特許番号
- US05866611
反応ノート
読み込み中…