Hydrochloric Acid → 2-Mercapto-1,3-benzoxazole-5-carboxylic acid methyl ester

HRID 36317

反応式

HRID 36317 の反応式
[NH2:1][C:2]1[CH:7]=[C:6]([C:8]([O:10][CH3:11])=[O:9])[CH:5]=[CH:4][C:3]=1[OH:12].[K+].C(O[C:17]([S-])=[S:18])C.Cl>N1C=CC=CC=1>[CH3:11][O:10][C:8]([C:6]1[CH:5]=[CH:4][C:3]2[O:12][C:17](=[S:18])[NH:1][C:2]=2[CH:7]=1)=[O:9]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 10815Methyl 3-amino-4-hydroxybenzoateHCID 2735045Potassium ethylxanthate

生成物 1

HCID 53069482-Mercapto-1,3-benzoxazole-5-carboxylic acid methyl ester収率 95%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

In a round bottom flask equipped with a mechanical stirrer, reflux condenser and drying tube were placed 2-amino-4-methoxycarbonylphenol (8,3 g, 0.05 mole), O-ethylxanthic acid potassium salt (8.8 g, 0.055 mole) and pyridine (125 mL). The mixture was stirred and heated at reflux for 2 hours and cooled to room temperature. The mixture was poured into ice and concentrated HCl (50 mL). The product was collected as a solid and washed thoroughly with water. The material was air dried to give 9.9 g (95%) of the 5-methoxycarbonylbenzoxazol-2-thione as a white powder, m.p. 218°-221° C.

後処理

  1. customIn a round bottom flask equipped with a mechanical stirrer
  2. temperaturereflux condenser
  3. customdrying tube
  4. temperatureheated
  5. temperatureat reflux for 2 hours
  6. customThe product was collected as a solid
  7. washwashed thoroughly with water
  8. customdried

出典と根拠

ORDレコード
ord-8fd265b3a6134e339dc6418af3aae6b0
出典データセット
uspto-grants-1995_05
特許番号
US05413905

関連ノート

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