Azobisisobutyronitrile → 3-Phenyl-2-chloro-6-bromomethylpyridine
反応式
[C:1]1([C:7]2[C:8]([Cl:14])=[N:9][C:10]([CH3:13])=[CH:11][CH:12]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C1C(=O)N([Br:22])C(=O)C1.CC(N=NC(C#N)(C)C)(C#N)C>C(Cl)(Cl)(Cl)Cl>[C:1]1([C:7]2[C:8]([Cl:14])=[N:9][C:10]([CH2:13][Br:22])=[CH:11][CH:12]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1参加物
5
実験手順
A solution of 3-Phenyl-2-chloro-6-methylpyridine (0.094 g, 0.462 mmol), NBS (0.086 g, 0.485 mmol) and AIBN (0.008 g, 0.046mmol) in CCl4 (3 mL) were heated at reflux for 2 hours. The solvent was evaporated and the residue chromatographed (Silica gel, 100% CH2Cl2 to afford the title compound.
後処理
- temperatureat reflux for 2 hours
- customThe solvent was evaporated
- customthe residue chromatographed (Silica gel, 100% CH2Cl2
出典と根拠
- ORDレコード
- ord-6d7d8198179a4f568c3b52dbfa301801
- 出典データセット
- uspto-grants-1999_02
- 特許番号
- US05872136
反応ノート
読み込み中…