Sodium amide → 2-Amino-3-Phenyl-6-methylpyridine

HRID 363199ノート

反応式

HRID 363199 の反応式
[C:1]1([C:7]2[CH:8]=[N:9][C:10]([CH3:13])=[CH:11][CH:12]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2-:14].[Na+]>CCN(C1C=CC=CC=1)CC>[NH2:14][C:8]1[C:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)=[CH:12][CH:11]=[C:10]([CH3:13])[N:9]=1

参加物

4

反応物 2

HCID 24533Sodium amideHCID 767442-Methyl-5-phenylpyridine

生成物 1

HCID 463146392-Amino-3-Phenyl-6-methylpyridine

試薬・触媒・溶媒 1

HCID 7061N,N-Diethylaniline溶媒

実験手順

A solution of 3-phenyl-6-methyl pyridine (0.815 g, 4.82 mmol), and sodium amide (752 mg, 19.3 mmol) in diethylaniline (10 mL) was heated at 180° C. for 72 hours. The reaction was cooled and quenched with ice (100 g), and the mixture extracted with EtOAc. The organic extract was washed with brine (50 mL), dried (MgSO4), silica gel (100 g) was added and the solvent evaporated in vacuo.

後処理

  1. temperatureThe reaction was cooled
  2. customquenched with ice (100 g)
  3. extractionthe mixture extracted with EtOAc
  4. extractionThe organic extract
  5. washwas washed with brine (50 mL)
  6. dry with materialdried (MgSO4), silica gel (100 g)
  7. additionwas added
  8. customthe solvent evaporated in vacuo

出典と根拠

ORDレコード
ord-32a3396c1d2b456c8dbc096b5c0cb0df
出典データセット
uspto-grants-1999_02
特許番号
US05872136

反応ノート

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