Phosphorus tribromide → 1-(Bromomethyl)-3-chlorobenzene

HRID 36340

反応式

HRID 36340 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH2:5]O.P(Br)(Br)[Br:11]>O1CCCC1>[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH2:5][Br:11]

参加物

4

反応物 2

HCID 24614Phosphorus tribromideHCID 701173-Chlorobenzyl alcohol

生成物 1

HCID 698381-(Bromomethyl)-3-chlorobenzene

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
0 °C

実験手順

A solution of 260 ul of 3-chlorobenzyl alcohol dissolved in 2.5 ml of dry tetrahydrofuran is cooled to 0° C. and 120 ul of PBr3 added. The reaction is stirred for 3 hours and extracted with ether. The organic layer is washed with saturated sodium bicarbonate and evaporated to give the desired product.

後処理

  1. extractionextracted with ether
  2. washThe organic layer is washed with saturated sodium bicarbonate
  3. customevaporated

出典と根拠

ORDレコード
ord-2e356bec6541419499a7e4e5503f2522
出典データセット
uspto-grants-1995_05
特許番号
US05414001

関連ノート

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