Phosphorus tribromide → 1-(Bromomethyl)-3-chlorobenzene
反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH2:5]O.P(Br)(Br)[Br:11]>O1CCCC1>[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH2:5][Br:11]参加物
4
反応条件
- 温度
- 0 °C
実験手順
A solution of 260 ul of 3-chlorobenzyl alcohol dissolved in 2.5 ml of dry tetrahydrofuran is cooled to 0° C. and 120 ul of PBr3 added. The reaction is stirred for 3 hours and extracted with ether. The organic layer is washed with saturated sodium bicarbonate and evaporated to give the desired product.
後処理
- extractionextracted with ether
- washThe organic layer is washed with saturated sodium bicarbonate
- customevaporated
出典と根拠
- ORDレコード
- ord-2e356bec6541419499a7e4e5503f2522
- 出典データセット
- uspto-grants-1995_05
- 特許番号
- US05414001
反応ノート
読み込み中…