Phosphorus tribromide → 3-Methoxybenzyl bromide

HRID 36341

反応式

HRID 36341 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][CH:10]=1)[CH2:6]O.P(Br)(Br)[Br:12]>O1CCCC1>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][CH:10]=1)[CH2:6][Br:12]

参加物

4

反応物 2

HCID 24614Phosphorus tribromideHCID 814373-Methoxybenzyl alcohol

生成物 1

HCID 40672073-Methoxybenzyl bromide

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of 270 ul of 3-methoxybenzyl alcohol in 2.5 ml of dry tetrahydrofuran is cooled to 0° C. and 120 ul PBr3 added, followed by stirring for three hours. The reaction mixture is extracted with ether and the organic layer washed with saturated sodium bicarbonate and evaporated to give the desired product.

後処理

  1. extractionThe reaction mixture is extracted with ether
  2. washthe organic layer washed with saturated sodium bicarbonate
  3. customevaporated

出典と根拠

ORDレコード
ord-d0021b55fed847d8be332381521d5721
出典データセット
uspto-grants-1995_05
特許番号
US05414001

関連ノート

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