Phosphorus tribromide → 3-Methoxybenzyl bromide
反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][CH:10]=1)[CH2:6]O.P(Br)(Br)[Br:12]>O1CCCC1>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][CH:10]=1)[CH2:6][Br:12]参加物
4
実験手順
A solution of 270 ul of 3-methoxybenzyl alcohol in 2.5 ml of dry tetrahydrofuran is cooled to 0° C. and 120 ul PBr3 added, followed by stirring for three hours. The reaction mixture is extracted with ether and the organic layer washed with saturated sodium bicarbonate and evaporated to give the desired product.
後処理
- extractionThe reaction mixture is extracted with ether
- washthe organic layer washed with saturated sodium bicarbonate
- customevaporated
出典と根拠
- ORDレコード
- ord-d0021b55fed847d8be332381521d5721
- 出典データセット
- uspto-grants-1995_05
- 特許番号
- US05414001
反応ノート
読み込み中…