Ethyl Acetate → Benzenebutanal, 4-(phenylmethoxy)-

HRID 363802

反応式

HRID 363802 の反応式
S([O-])([O-])(=O)=O.[Mg+2].[CH:7]1[C:12]([C@@H:13](O)[CH2:14]N)=[CH:11][C:10]([OH:17])=[C:9](O)[CH:8]=1.[C:19]([O:22][CH2:23][CH3:24])(=O)[CH3:20]>[Pt]>[CH2:23]([O:22][C:19]1[CH:20]=[CH:11][C:12]([CH2:7][CH2:8][CH2:9][CH:10]=[O:17])=[CH:13][CH:14]=1)[C:24]1[CH:11]=[CH:12][CH:7]=[CH:8][CH:9]=1

参加物

5

反応物 3

HCID 8857Ethyl Acetate3 回HCID 24083Sulfuric acid magnesium salt (1:1)HCID 439260Norepinephrine

生成物 1

HCID 11086308Benzenebutanal, 4-(phenylmethoxy)-

試薬・触媒・溶媒 1

HCID 23939Platinum触媒

実験手順

A solution of 4-(4-benzyloxyphenyl)-butanal (52.4 g, 206 mmol) in 150 mL ethyl acetate (1.4M solution) was prepared and set aside. 10% platinum on carbon (3.40 g) was prewetted with ethyl acetate and transferred to the reactor. To this was added magnesium sulfate (60.0 g, 500 mmol), followed by the ethyl acetate solution of (trimethylsilyl)-protected norepinephrine prepared as described in Example 1.

後処理

  1. customprepared

出典と根拠

ORDレコード
ord-becb9cf850d841398405eae6e1336a80
出典データセット
uspto-grants-1999_02
特許番号
US05874601

関連ノート

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