Thymine → Thymine

HRID 36404

反応式

HRID 36404 の反応式
[OH-].[CH2:2]([N+:6]([CH2:15][CH2:16][CH2:17][CH3:18])([CH2:11][CH2:12][CH2:13][CH3:14])[CH2:7][CH2:8][CH2:9][CH3:10])[CH2:3][CH2:4][CH3:5].[NH:19]1[CH:27]=[C:25]([CH3:26])[C:23](=[O:24])[NH:22][C:20]1=[O:21]>CN(C)C=O>[CH2:15]([N+:6]([CH2:2][CH2:3][CH2:4][CH3:5])([CH2:7][CH2:8][CH2:9][CH3:10])[CH2:11][CH2:12][CH2:13][CH3:14])[CH2:16][CH2:17][CH3:18].[NH:19]1[CH:27]=[C:25]([CH3:26])[C:23](=[O:24])[NH:22][C:20]1=[O:21]

参加物

5

反応物 2

HCID 1135ThymineHCID 2723671Tetrabutylammonium Hydroxide

生成物 2

HCID 1135ThymineHCID 16028Tetrabutylammonium

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

1.5M Tetra(n-butyl)ammonium hydroxide (4.22 ml., 6.335 mmole) was added to a suspension of thymine (0.913 g., 7.24 mmole) in dimethylformamide (15 ml.). The mixture was stirred for 10 minutes, and the dimethylformamide was removed in vacuo. Additional dimethylformamide (20 ml.) was added to the white residue, and removed in vacuo. This process was repeated four times and the residue was dried under a vacuum (0.1 mm) at 50° C. overnight affording the tetra (n-butyl) ammonium salt of thymine.

後処理

  1. customthe dimethylformamide was removed in vacuo
  2. additionAdditional dimethylformamide (20 ml.) was added to the white residue
  3. customremoved in vacuo
  4. customthe residue was dried under a vacuum (0.1 mm) at 50° C. overnight

出典と根拠

ORDレコード
ord-9563b5c96ba04b2ba694ef5e71cd858a
出典データセット
uspto-grants-1995_05
特許番号
US05414096

関連ノート

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