(3,4-Dimethoxyphenyl)acetic acid → (3,4-Dimethoxyphenyl)acetyl chloride

HRID 364067

反応式

HRID 364067 の反応式
S(Cl)([Cl:3])=O.[CH3:5][O:6][C:7]1[CH:8]=[C:9]([CH2:15][C:16]([OH:18])=O)[CH:10]=[CH:11][C:12]=1[O:13][CH3:14]>C(Cl)Cl>[CH3:5][O:6][C:7]1[CH:8]=[C:9]([CH2:15][C:16]([Cl:3])=[O:18])[CH:10]=[CH:11][C:12]=1[O:13][CH3:14]

参加物

4

反応物 2

HCID 7139(3,4-Dimethoxyphenyl)acetic acidHCID 24386Thionyl Chloride

生成物 1

HCID 3604458(3,4-Dimethoxyphenyl)acetyl chloride

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Thionyl chloride (600 ml) is added dropwise, with stirring, over a period of 2 hours, to a suspension of 3,4-dimethoxy-phenylacetic acid (549.4 g) in methylene chloride (600 ml). After the development of gas has ended (16 hours) the mixture is refluxed for a further hour. After the highly volatile components have been removed the residue is distilled in vacuo.

後処理

  1. custom(16 hours)
  2. temperatureis refluxed for a further hour
  3. customAfter the highly volatile components have been removed the residue
  4. distillationis distilled in vacuo

出典と根拠

ORDレコード
ord-84c79170daf541418aa1ecc3cbc7f128
出典データセット
uspto-grants-1986_08
特許番号
US04604389

関連ノート

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