O-Methylhydroxylamine hydrochloride → HCID 86740953、化合物
反応式
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=O)[CH2:9][C:10]1[CH:15]=[N:14][CH:13]=[CH:12][N:11]=1.Cl.[CH3:18][O:19][NH2:20]>N1C=CC=CC=1>[CH3:18][O:19][N:20]=[C:8]([C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[Cl:1])[CH2:9][C:10]1[CH:15]=[N:14][CH:13]=[CH:12][N:11]=1参加物
4
実験手順
3 g of 2'-chloro-2-(2-pyrazinyl)-acetophenone and 0.8 g of O-methylhydroxylamine hydrochloride are dissolved in 10 ml of pyridine and the mixture is heated at 80° for 30 minutes. The pyridine is then removed under reduced pressure and water is added to the crude product. Thereupon, the mixture is extracted with ethyl acetate and the organic phase is dried over sodium sulfate and concentrated to yield 2'-chloro-2-(2-pyrazinyl)-acetophenone O-methyl oxime as an oil.
後処理
- temperaturethe mixture is heated at 80° for 30 minutes
- customThe pyridine is then removed under reduced pressure and water
- additionis added to the crude product
- extractionThereupon, the mixture is extracted with ethyl acetate
- dry with materialthe organic phase is dried over sodium sulfate
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-d5aab528030d4a7dad87221b8528c5fb
- 出典データセット
- uspto-grants-1986_08
- 特許番号
- US04605656
反応ノート
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