Water → 2'-(Ethoxycarbonyloxy)4,4',6'-trimethoxychalcone

HRID 364659

反応式

HRID 364659 の反応式
Cl[C:2]([O:4][CH2:5][CH3:6])=[O:3].OC1C=[C:24]([O:26][CH3:27])[CH:23]=[C:22]([O:28][CH3:29])[C:9]=1[C:10](=[O:21])[CH:11]=[CH:12][C:13]1[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=1.[OH2:30].N1[CH:36]=[CH:35]C=CC=1>>[CH2:35]([O:3][C:2]([O:4][C:5]1[CH:6]=[C:24]([O:26][CH3:27])[CH:23]=[C:22]([O:28][CH3:29])[C:9]=1[C:10](=[O:21])[CH:11]=[CH:12][C:13]1[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=1)=[O:30])[CH3:36]

参加物

5

反応物 4

HCID 962WaterHCID 1049PyridineHCID 10928Ethyl chloroformateHCID 235736Flavokavain A

生成物 1

HCID 537547452'-(Ethoxycarbonyloxy)4,4',6'-trimethoxychalcone収率 53%

実験手順

Ethyl chloroformate (216 mg) was added dropwise to a solution of 2'-hydroxy-4,4',6'-trimethoxychalcone (314 mg) in 5 ml of pyridine. After stirring at room temperature for 30 minutes, the mixture was poured into water (30 ml). The mixture was extracted with three 30 ml portions of chloroform, and the combined extracts were washed with water, dried over Na2SO4 and evaporated to give an oily residue. Crystallization of the residue from methanol gave 202 mg (53% yield) of 2'-(ethoxycarbonyloxy)4,4',6'-trimethoxychalcone as pale yellow prisms; m.p. 107° C.

後処理

  1. extractionThe mixture was extracted with three 30 ml portions of chloroform
  2. washthe combined extracts were washed with water
  3. dry with materialdried over Na2SO4
  4. customevaporated
  5. customto give an oily residue
  6. customCrystallization of the residue from methanol

出典と根拠

ORDレコード
ord-886c005a8ab34ef0b612cdf910c5845e
出典データセット
uspto-grants-1986_08
特許番号
US04605674

関連ノート

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