Water → 1-Bromoethyl ethyl carbonate

HRID 364870

反応式

HRID 364870 の反応式
[Br-:1].[Li+].[C:3](=[O:11])([O:7][CH:8](Cl)[CH3:9])[O:4][CH2:5][CH3:6].O>[Br-].C([N+](C)(C)C)CCCCCCCCCCCCCCC.ClCCl>[C:3](=[O:11])([O:7][CH:8]([Br:1])[CH3:9])[O:4][CH2:5][CH3:6]

参加物

6

反応物 3

HCID 962WaterHCID 82050Lithium BromideHCID 162095Carbonic acid, 1-chloroethyl ethyl ester

生成物 1

HCID 30215501-Bromoethyl ethyl carbonate収率 76%

試薬・触媒・溶媒 2

HCID 5974Hexadecyltrimethylammonium Bromide触媒HCID 6344Dichloromethane溶媒

反応条件

温度
35 °C

実験手順

A mixture of lithium bromide (43 g, 0.5 m), ethyl alphachloroethyl carbonate (15.3 g, 0.1 m); water (100 ml), dichloromethane (100 ml) and cetyl trimethyl ammonium bromide (1.5 g) was stirred at ambient temperature for 24 hours. The aqueous layer was removed and replaced by a fresh solution of lithium bromide (26 g, 0.3 m) in water (40 ml) containing cetyl trimethyl ammonium bromide (1 g). After stirring for a further 24 hours during which time the temperature was raised to 35° C., the organic layer was separated, dried and vacuum distilled to afford after repeated fractionation the new compound, ethyl alpha-bromoethyl carbonate (15.0 g, 76% yield) having a boiling point of 90°-92° C. at 35 mms of mercury pressure.

後処理

  1. customThe aqueous layer was removed
  2. additioncontaining cetyl trimethyl ammonium bromide (1 g)
  3. customthe organic layer was separated
  4. customdried
  5. distillationvacuum distilled
  6. customto afford

出典と根拠

ORDレコード
ord-75c976b030f141568083f517c6320f1f
出典データセット
uspto-grants-1986_08
特許番号
US04606865

関連ノート

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