Water → HCID 13292600、化合物

HRID 364997ノート

反応式

HRID 364997 の反応式
[C:1]([C:3]1[CH:8]=[CH:7][N:6]=[C:5]([CH2:9][OH:10])[CH:4]=1)#[N:2].[H-].[Al+3].[Li+].[H-].[H-].[H-].[OH-].[Na+].O>O1CCCC1>[NH2:2][CH2:1][C:3]1[CH:8]=[CH:7][N:6]=[C:5]([CH2:9][OH:10])[CH:4]=1

参加物

6

反応物 4

HCID 962WaterHCID 14798Sodium HydroxideHCID 132925992-(Hydroxymethyl)pyridine-4-carbonitrileHCID 21226445Aluminium lithium hydride

生成物 1

HCID 13292600HCID 13292600、化合物収率 54.4%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒3 回

実験手順

A solution of 4-cyano-2-hydroxymethylpyridine (0.5 g) in tetrahydrofuran (25 ml) was added dropwise over 20 minutes to a stirred mixture of lithium aluminium hydride (0.25 g) in tetrahydrofuran (30 ml) and the mixture was stirred at room temperature for 2 hours. Wet tetrahydrofuran followed by 0.35 ml of 16% w/w aqueous sodium hydroxide and water were added and the mixture was filtered. The filtrate was evaporated to give crude 4-aminomethyl-2-hydroxymethylpyridine (0.28 g).

後処理

  1. additionwere added
  2. filtrationthe mixture was filtered
  3. customThe filtrate was evaporated

出典と根拠

ORDレコード
ord-e89e369c398640a0beddf2a8300ce4a8
出典データセット
uspto-grants-1986_08
特許番号
US04607107

反応ノート

読み込み中…