1,2-Dimethylhydrazine → 3-Hydroxy-1,2,4-trimethyl-5-pyrazolone

HRID 365173

反応式

HRID 365173 の反応式
[CH3:1][CH:2]([C:8]([O:10]CC)=O)[C:3](OCC)=[O:4].[CH3:13][NH:14][NH:15][CH3:16].C[O-].[Na+]>CO>[OH:10][C:8]1[N:14]([CH3:13])[N:15]([CH3:16])[C:3](=[O:4])[C:2]=1[CH3:1]

参加物

5

反応物 3

HCID 13221,2-DimethylhydrazineHCID 11857Diethyl methylmalonateHCID 10942334Sodium Methoxide

生成物 1

HCID 128188533-Hydroxy-1,2,4-trimethyl-5-pyrazolone

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Diethyl methylmalonate and N,N'-dimethylhydrazine are heated under reflux for 170 hours in methanol in the presence of sodium methylate under an atmosphere of nitrogen. 3-Hydroxy-1,2,4-trimethyl-5-pyrazolone is obtained in the form of colorless crystals which, after recrystallization from ethyl acetate, melt at 87°-89° C.

出典と根拠

ORDレコード
ord-da58efdd8cfd44639ad1ce4e0173a134
出典データセット
uspto-grants-1986_08
特許番号
US04608383

関連ノート

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