Ammonia → 4-(Bromoheptyl)-2,6-dimethyl pyridine
反応式
[N:1]1[C:6]([CH3:7])=[CH:5][C:4]([CH3:8])=[CH:3][C:2]=1[CH3:9].[Br:10][CH:11](Br)[CH2:12][CH2:13][CH2:14][CH2:15][CH3:16].N>O1CCCC1>[Br:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:8][C:4]1[CH:5]=[C:6]([CH3:7])[N:1]=[C:2]([CH3:9])[CH:3]=1参加物
5
反応条件
- 温度
- -40 °C
実験手順
Sodium amide was formed from sodium (1.0 g, 43.5 mmol) in liquid ammonia (100 ml) according to Example 1. Collidine (1) (5.0 g, 41.3 mmol) dissolved in tetrahydrofuran (5 ml) was added dropwise and after 45 min a well-cooled solution of dibromohexane (51.2 g, 210 mmol) in THF (100 ml) was added quickly. The reaction mixture was stirred for 1 h at -40° C. and then left stirring overnight during which times ammonia evaporated.
後処理
- additionwas added quickly
- waitleft
- customevaporated
出典と根拠
- ORDレコード
- ord-2f6847b9949c45f795afa97ecc22a46c
- 出典データセット
- uspto-grants-2000_10
- 特許番号
- US06127529
反応ノート
読み込み中…