Trimethyl borate → (1-Methyl-1H-indol-2-yl)boronic acid
反応式
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3]1.C([Li])(CC)C.[B:16](OC)([O:19]C)[O:17]C>C1COCC1>[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[C:3]1[B:16]([OH:19])[OH:17]参加物
5
反応条件
- 温度
- -78 °C
実験手順
1-Methylindole (0.38 mL, 3 mmol) was dissolved in THF (10 mL), and the solution was cooled to -78° C. To this solution was added sec-butyllithium (1.9 mL, 2.5 mmol), and the reaction mixture was stirred for 20 minutes. Trimethyl borate (0.34 mnL, 3 mmol) was added at -78° C., and the mixture was stirred and allowed to warm to room temperature. The reaction was quenched with water, and the solvents were removed under vacuum. The residue was taken directly to the next step.
後処理
- stirringthe mixture was stirred
- temperatureto warm to room temperature
- customThe reaction was quenched with water
- customthe solvents were removed under vacuum
出典と根拠
- ORDレコード
- ord-e0897dc319364c3086dff7a8a8ea75f2
- 出典データセット
- uspto-grants-2000_10
- 特許番号
- US06127386
反応ノート
読み込み中…