Hydrochloric Acid → 3-Bromo-6-hydroxy-2-methylbenzoic acid

HRID 365955

反応式

HRID 365955 の反応式
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([OH:14])=[C:6]([C:12]=1[CH3:13])[C:7]([O:9]CC)=[O:8].C(O)C.[OH-].[Na+].Cl>O>[OH:14][C:5]1[CH:4]=[CH:3][C:2]([Br:1])=[C:12]([CH3:13])[C:6]=1[C:7]([OH:9])=[O:8]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14798Sodium HydroxideHCID 23293235Ethyl 3-bromo-6-hydroxy-2-methylbenzoate

生成物 1

HCID 110534513-Bromo-6-hydroxy-2-methylbenzoic acid

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 1A (20.2 g, 0.078 mol), ethanol (150 ml) and an aqueous sodium hydroxide (12 g, 0.3 mol in 100 ml water) is heated under reflux with stirring for 16 hours. The reaction mixture is cooled to room temperature, diluted with water (600 ml) and acidified with concentrated hydrochloric acid. The precipitate is collected and washed with water yielding 18.45 g (100%) white crystals with a melting point of 163-165° C.

後処理

  1. temperatureunder reflux
  2. customThe precipitate is collected
  3. washwashed with water yielding 18.45 g (100%) white crystals with a melting point of 163-165° C.

出典と根拠

ORDレコード
ord-1ca1a3967616418894d2d29c8c92c8a9
出典データセット
uspto-grants-2000_10
特許番号
US06127570

関連ノート

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