Water → N-(4-iodophenyl)-2-methylpropanamide

HRID 3667

反応式

HRID 3667 の反応式
[I:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][CH:3]=1.N1C=CC=CC=1.[C:15](Cl)(=[O:19])[CH:16]([CH3:18])[CH3:17].O>C(#N)C>[I:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][C:15](=[O:19])[CH:16]([CH3:18])[CH3:17])=[CH:4][CH:3]=1

参加物

6

反応物 4

HCID 962WaterHCID 1049PyridineHCID 108934-IodoanilineHCID 62325Isobutyryl chloride2 回

生成物 1

HCID 836020N-(4-iodophenyl)-2-methylpropanamide収率 97.4%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

To a dispersion of p-iodoaniline (219.0 g, 1 mol) in acetonitrile(1000 ml) was added pyridine (81.0 ml, 1 mol). Isobutyryl chloride (100.5 ml, 1 mol) was added dropwise to the mixture over 1 hour in an ice bath. The mixture was further stirred for one hour following the addition of isobutyryl chloride and to the mixture was added water (3000 ml). Precipitated crystalline solids were collected by filtration to give N-(4-iodophenyl)isobutyramide (281.7 g, Yield: 97%).

後処理

  1. filtrationPrecipitated crystalline solids were collected by filtration

出典と根拠

ORDレコード
ord-1e9f35d9308c4443ac4377883641dd28
出典データセット
uspto-grants-1998_03
特許番号
US05734063

関連ノート

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