Acetic Acid → 5-Amino-1-(chloromethyl)-3-[(e)-3-methoxycinnamoyl]-1,2-dihydro-3h-benz[e]indole

HRID 366829ノート

反応式

HRID 366829 の反応式
[Cl:1][CH2:2][CH:3]1[C:11]2[C:10]3[CH:12]=[CH:13][CH:14]=[CH:15][C:9]=3[C:8]([N+:16]([O-])=O)=[CH:7][C:6]=2[N:5]([C:19](=[O:30])/[CH:20]=[CH:21]/[C:22]2[CH:27]=[CH:26][CH:25]=[C:24]([O:28][CH3:29])[CH:23]=2)[CH2:4]1.CO.O.CC(O)=O>C1COCC1.[Fe]>[NH2:16][C:8]1[C:9]2[CH:15]=[CH:14][CH:13]=[CH:12][C:10]=2[C:11]2[CH:3]([CH2:2][Cl:1])[CH2:4][N:5]([C:19](=[O:30])/[CH:20]=[CH:21]/[C:22]3[CH:27]=[CH:26][CH:25]=[C:24]([O:28][CH3:29])[CH:23]=3)[C:6]=2[CH:7]=1

参加物

7

反応物 4

HCID 176Acetic AcidHCID 887MethanolHCID 962WaterHCID 100252921-(chloromethyl)-3-[(E)-3-methoxycinnamoyl]-5-nitro-1,2-dihydro-3H-benz[e]indole

生成物 1

HCID 54701445-Amino-1-(chloromethyl)-3-[(e)-3-methoxycinnamoyl]-1,2-dihydro-3h-benz[e]indole収率 54%

試薬・触媒・溶媒 2

HCID 23925Iron触媒HCID 8028Tetrahydrofuran溶媒

実験手順

To a hot solution of 14l (110 mg, 0.26 mmol) in THF (10 mL) was added in sequential fashion MeOH (5 mL), H2O (2 mL), AcOH (0.2 mL) and Fe powder (0.5 mL). The mixture was heated at reflux for 1 h, then basified with CaO (1 g), filtered, concentrated to a small volume under reduced pressure below 30° C. and diluted with water. The resulting precipitate was chromatographed on silica gel, eluting with CH2Cl2 /EtOAc (9:1), to give a solid which was recrystallised from CH2Cl2 /petroleum ether to give 15l (55 mg, 54%) mp >200° C. 1H NMR [(CD3)2SO] δ 8.06 (d, J=8.5 Hz, 1 H, H-6), 7.83 (bs, 1 H, H-4), 7.72 (d, J=8.3 Hz, 1 H, H-9), 7.63 (d, J=15.4 Hz, 1 H, PhC=CH), 7.44 (t, J=7.4 Hz, 1 H, H-8), 7.40-7.34 (m, 3 H, PhH), 7.26 (t, partially obscured, J=7.9 Hz, 1 , H-7), 7.22 (d, J=15.4 Hz, 1 h, PhCH=CH), 7.04-6.97 (m, 1 H, PhH), 5.95 (br s, 2 H, NH2), 4.53-4.38 (m, 2 H, H-2), 4.19-4.08 (m, 1 H, H-1), 3.95 (dd, J=11.0, 2.9 Hz, 1 H, CHHCl), 3.83 (s, 3 H, OCH3), 3.76 (dd, J=10.9, 8.1 Hz, 1 H, CHHCl). Anal. Calculated for C23H21ClN2O2 : C, 70.3; H, 5.4; N, 7.1; Cl, 9.0. Found: C, 70.4; H, 5.6; N, 6.9; Cl, 9.1%.

後処理

  1. temperatureThe mixture was heated
  2. temperatureat reflux for 1 h
  3. filtrationfiltered
  4. concentrationconcentrated to a small volume under reduced pressure below 30° C.
  5. additiondiluted with water
  6. customThe resulting precipitate was chromatographed on silica gel
  7. washeluting with CH2Cl2 /EtOAc (9:1)
  8. customto give a solid which
  9. customwas recrystallised from CH2Cl2 /petroleum ether

出典と根拠

ORDレコード
ord-da936fa627964949bf2d0ab10b93d3c3
出典データセット
uspto-grants-2000_10
特許番号
US06130237

反応ノート

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