Acetophenone → Ccris 2231
反応式
[OH-].[Na+].[CH:3](=[O:12])[C:4]1[CH:9]=[CH:8][C:7]([O:10][CH3:11])=[CH:6][CH:5]=1.[C:13]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)(=O)[CH3:14]>CCO.O>[CH3:11][O:10][C:7]1[CH:8]=[CH:9][C:4]([C:3](=[O:12])[CH:14]=[CH:13][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[CH:5][CH:6]=1参加物
6
実験手順
Step A Add 10% aqueous NaOH (38 mL) to a solution of p-anisaldehyde (25 mL, 0.206 mol) and acetophenone (23.97 mL, 0.206 mol) in EtOH (500 mL). Stir the mixture at room temperature over night. Dilute the mixture with water and extract with ether. Combine the ethereal extracts, wash with water and brine, dry over Na2SO4 and concentrate to a solid. Recrystallize the solid from ether/hexanes to provide 27.51 g (56%) of 4'-methoxychalcone, mp 72°-74° C.
後処理
- extractionextract with ether
- washwash with water and brine
- dry with materialdry over Na2SO4
- concentrationconcentrate to a solid
- customRecrystallize the solid from ether/hexanes
出典と根拠
- ORDレコード
- ord-8a78853258fc48d2bcf415d810e7317d
- 出典データセット
- uspto-grants-1995_05
- 特許番号
- US05416118
反応ノート
読み込み中…