Methylamine → 3,5,6-Trifluoro-N-methylpyridin-2-amine
反応式
[C:1](#[N:3])C.[F:4][C:5]1[C:10]([F:11])=[CH:9][C:8]([F:12])=[C:7](F)[N:6]=1.CN>C(Cl)(Cl)Cl>[F:12][C:8]1[C:7]([NH:3][CH3:1])=[N:6][C:5]([F:4])=[C:10]([F:11])[CH:9]=1参加物
5
反応条件
- 温度
- 50 °C
実験手順
To 10 ml of acetonitrile were added 4.5 g of 2,3,5,6-tetrafluoropyridine and 10 ml of methylamine (10% aqueous solution), and the mixture was stirred at 50° C. for 2 hours. To the solution was added 50 ml of chloroform, and the mixture was washed four times with 250 ml of distilled water. The chloroform layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to obtain the title compound as a pale brown crude oil.
後処理
- washthe mixture was washed four times with 250 ml of distilled water
- dry with materialThe chloroform layer was dried over anhydrous magnesium sulfate
- concentrationconcentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-fc334f0e902840959b27aeeb3964f351
- 出典データセット
- uspto-grants-2000_10
- 特許番号
- US06133284
反応ノート
読み込み中…