Acetonitrile → 4-(t-Butylamino)-2,3,5,6-tetrafluoropyridine

HRID 368418

反応式

HRID 368418 の反応式
C(#N)C.[F:4][C:5]1[N:10]=[C:9]([F:11])[C:8]([F:12])=[C:7](F)[C:6]=1[F:14].[C:15]([NH2:19])([CH3:18])([CH3:17])[CH3:16]>C(Cl)(Cl)Cl>[C:15]([NH:19][C:7]1[C:8]([F:12])=[C:9]([F:11])[N:10]=[C:5]([F:4])[C:6]=1[F:14])([CH3:18])([CH3:17])[CH3:16]

参加物

5

反応物 3

HCID 6342AcetonitrileHCID 6385Tert-ButylamineHCID 69690Pentafluoropyridine

生成物 1

HCID 221211594-(t-Butylamino)-2,3,5,6-tetrafluoropyridine収率 71.4%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

To 100 ml of acetonitrile was added 24.5 g of pentafluoropyridine, and the mixture was stirred in an ice bath simultaneously with the dropwise addition of 30 g of t-butylamine. When the mixture warmed to room temperature, 150 ml of chloroform was added, and the mixture was washed twice with 800 ml of distilled water. The chloroform layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to obtain 23 g of the title compound as a pale yellow oil.

後処理

  1. washthe mixture was washed twice with 800 ml of distilled water
  2. dry with materialThe chloroform layer was dried over anhydrous magnesium sulfate
  3. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-c491565e5fa549ff8464593fe08b775f
出典データセット
uspto-grants-2000_10
特許番号
US06133284

関連ノート

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