Diethylene Glycol Monoethyl Ether → 3-[4-(4-m-Methoxyphenylpiperazino)butyl]indole-5-carboxamide

HRID 36956

反応式

HRID 36956 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([N:9]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][CH2:18][C:19]3[C:27]4[C:22](=[CH:23][CH:24]=[C:25]([C:28]#[N:29])[CH:26]=4)[NH:21][CH:20]=3)[CH2:11][CH2:10]2)[CH:6]=[CH:7][CH:8]=1.[OH-].[Na+].C([O:34]CCOCCO)C>O>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([N:9]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][CH2:18][C:19]3[C:27]4[C:22](=[CH:23][CH:24]=[C:25]([C:28]([NH2:29])=[O:34])[CH:26]=4)[NH:21][CH:20]=3)[CH2:11][CH2:10]2)[CH:6]=[CH:7][CH:8]=1

参加物

5

反応物 3

HCID 8146Diethylene Glycol Monoethyl EtherHCID 14798Sodium HydroxideHCID 199364823-[4-(4-m-Methoxyphenylpiperazino)butyl]-5-cyanoindole

生成物 1

HCID 199364563-[4-(4-m-Methoxyphenylpiperazino)butyl]indole-5-carboxamide

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 30.6 g of 3-[4-(4-m-methoxyphenylpiperazino)butyl]-5-cyanoindole, 27.1 g of NaOH, 520 ml of water and 420 ml of diethylene glycol monoethyl ether is stirred for 3 hours at a bath temperature of 140°. It is cooled and worked up in a conventional manner, and 3-[4-(4-m-methoxyphenylpiperazino)butyl]indole-5-carboxamide is obtained.

後処理

  1. temperatureIt is cooled

出典と根拠

ORDレコード
ord-f6566778685e4c7d97edb5d95ee8c66c
出典データセット
uspto-grants-1995_05
特許番号
US05418237

関連ノート

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