5-Chloro-2-nitrobenzoic acid → 5-Chloro-2-nitrobenzoyl chloride

HRID 370069

反応式

HRID 370069 の反応式
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N+:11]([O-:13])=[O:12])=[C:6]([CH:10]=1)[C:7](O)=[O:8].C(Cl)(=O)C([Cl:17])=O>C(Cl)Cl.CN(C=O)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N+:11]([O-:13])=[O:12])=[C:6]([CH:10]=1)[C:7]([Cl:17])=[O:8]

参加物

5

反応物 2

HCID 172865-Chloro-2-nitrobenzoic acidHCID 65578Oxalyl chloride

生成物 1

HCID 27236855-Chloro-2-nitrobenzoyl chloride収率 104.5%

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide触媒HCID 6344Dichloromethane溶媒

実験手順

To a suspension of 5-chloro-2-nitrobenzoic acid (21 g, 100 mmol) in dry methylene chloride (200 mL) at 0° C. were added several drops of DMF, followed by oxalyl chloride (13 mL, 150 mmol). The reaction was warmed to ambient temperature. After 16 hours the solvents were removed and the viscous oil dried in vacuo to afford 23 g (quantitative yield) of 5-chloro-2-nitrobenzoyl chloride; NMR (CDCl3) 8.1 (d, 1), 7.7 (m, 2) ppm.

後処理

  1. customAfter 16 hours the solvents were removed
  2. customthe viscous oil dried in vacuo

出典と根拠

ORDレコード
ord-334ab236062a4121888a04ebcb61115d
出典データセット
uspto-grants-2000_10
特許番号
US06140351

関連ノート

読み込み中…