tert-Butanol → tert-Butyl Crotonate

A solution of t-BuOH (0.50 mol, 37.1 g, 47.8 mls) in THF (500 mls) is cooled to 5° C.; then over a 30 minute period n-BuLi (0.56 mol., 350 ml, 1.6 M) is added to the solution. The resulting mixture is stirred for 40 minutes at room temperature. Crotyl chloride (0.50 mol., 52.3 g, 47.9 mls) in THF (250 mls) is added to the reaction mixture at room temperature over a 15 minute period. The resulting mixture is heated under reflux for 50 minutes. The reaction mixture is cooled to 0° C. and ice-water (800 mls) is added. The layers are separated and the aqueous layer is extracted with Et2O (3×600 mls). The organic phases are combined, dried over Na2SO4, filtered and concentrated by rotary evaporation to give a red oil. Distillation (55° C., 22 mm) yields t-butyl crotonate: 1H NMR (300 MHz, CDCl3) δ 1.46 (s, 9H), 1.83 (dd, J is 6.9, 1.7 Hz, 3H), 5.74 (dq, J is 15.5, 1.7 Hz, 1H), 6.85 (dq, J is 15.5, 6.9 Hz, 1H).

1. temperatureThe resulting mixture is heated
2. temperatureunder reflux for 50 minutes
3. temperatureThe reaction mixture is cooled to 0° C.
4. customThe layers are separated
5. extractionthe aqueous layer is extracted with Et2O (3×600 mls)
6. dry with materialdried over Na2SO4
7. filtrationfiltered
8. concentrationconcentrated by rotary evaporation
9. customto give a red oil
10. distillationDistillation (55° C., 22 mm)

ORDレコード

ord-11c99d2c33494f03bca2a524c4bb8813

出典データセット

uspto-grants-2000_10

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US06140510