Tetrahydrofuran → 4-[(2-Butyl imidazo(1,2-a)pyridine 3-yl) methyl]benzonitrile

HRID 37212ノート

反応式

HRID 37212 の反応式
Br[C:2]1[N:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]2=[N:4][C:3]=1[CH2:11][CH2:12][CH2:13][CH3:14].O1[CH2:19][CH2:18][CH2:17][CH2:16]1>[Pd].BrCC1C=CC(C#N)=CC=1.[Zn].O>[CH2:11]([C:3]1[N:4]=[C:5]2[CH:10]=[CH:9][CH:8]=[CH:7][N:6]2[C:2]=1[CH2:16][C:17]1[CH:13]=[CH:12][C:11]([C:3]#[N:4])=[CH:19][CH:18]=1)[CH2:12][CH2:13][CH3:14]

参加物

6

反応物 2

HCID 8028TetrahydrofuranHCID 151299083-Bromo-2-butylimidazo[1,2-a]pyridine

生成物 1

HCID 190324684-[(2-Butyl imidazo(1,2-a)pyridine 3-yl) methyl]benzonitrile

試薬・触媒・溶媒 3

HCID 23938Palladium触媒HCID 69459885HCID 69459885、化合物触媒HCID 962Water溶媒

実験手順

A mixture of 2 g of the product of Stage D, 100 ml of tetrahydrofuran and 1 -g of [tetra-bis(triphenylphosphine)] palladium was added to 35.9 ml of zinc 4-bromomethyl benzonitrile at ambient temperature and the mixture was refluxed for one hour. The mixture was allowed to return to ambient temperature, poured into water and extracted with ethyl acetate. The extracts were washed with a saturated aqueous solution of sodium chloride, dried, filtered and brought to dryness to obtain after chromatography on silica (ethyl acetate), 1.1 g of the expected product.

後処理

  1. temperaturethe mixture was refluxed for one hour
  2. customto return to ambient temperature
  3. extractionextracted with ethyl acetate
  4. washThe extracts were washed with a saturated aqueous solution of sodium chloride
  5. customdried
  6. filtrationfiltered

出典と根拠

ORDレコード
ord-548804b8b0344758893f2d65a8348415
出典データセット
uspto-grants-1995_05
特許番号
US05420138

反応ノート

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