Hydrochloric Acid → 1,2,3,4-Tetrahydro-4-methoxy-1-naphthylurea

HRID 372281ノート

反応式

HRID 372281 の反応式
[OH:1][CH:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]([NH:12][C:13]([NH2:15])=[O:14])[CH2:4][CH2:3]1.[H-].[Na+].[CH3:18]I.Cl>CN(C)C=O>[CH3:18][O:1][CH:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]([NH:12][C:13]([NH2:15])=[O:14])[CH2:4][CH2:3]1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 42945181,2,3,4-Tetrahydro-4-hydroxy-1-naphthylurea

生成物 1

HCID 203273121,2,3,4-Tetrahydro-4-methoxy-1-naphthylurea

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A 2.0 g sample of 1,2,3,4-tetrahydro-4-hydroxy-1-naphthylurea (cis/trans) is stirred in 10 ml of dry dimethylformamide and one equivalent of sodium hydride in mineral oil added at 0° C under a nitrogen atmosphere. After the addition is completed, 1.2 equivalents of methyl iodide is added and the reaction mixture stirred overnight. The mixture is carefully poured on ice, neutralized with hydrochloric acid and the title compound collected by filtration. Evaporation of the filtrate to dryness and washing the residue with water affords additional title compound.

後処理

  1. additionAfter the addition
  2. additionThe mixture is carefully poured on ice
  3. filtrationthe title compound collected by filtration
  4. customEvaporation of the filtrate to dryness
  5. washwashing the residue with water

出典と根拠

ORDレコード
ord-7e3a9aa6ebad4457a285fc2d2149992a
出典データセット
uspto-grants-1978_05
特許番号
US04089976

反応ノート

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