2-Hydroxyacetamide → 2-(4-Chloro-2-methylphenoxymethyl)-4-oxazolidinone

HRID 372342

反応式

HRID 372342 の反応式
[Cl:1][C:2]1[CH:11]=[CH:10][C:5]([O:6][CH2:7][CH:8]=[O:9])=[C:4]([CH3:12])[CH:3]=1.[C:13]([NH2:17])(=[O:16])[CH2:14]O>O1CCCC1.CCOCC>[Cl:1][C:2]1[CH:11]=[CH:10][C:5]([O:6][CH2:7][CH:8]2[NH:17][C:13](=[O:16])[CH2:14][O:9]2)=[C:4]([CH3:12])[CH:3]=1

参加物

5

反応物 2

HCID 690212-HydroxyacetamideHCID 123914592-(4-Chloro-2-methylphenoxy)acetaldehyde

生成物 1

HCID 123914922-(4-Chloro-2-methylphenoxymethyl)-4-oxazolidinone収率 18.2%

試薬・触媒・溶媒 2

HCID 3283Diethyl Ether溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

A solution containing 4.6g (0.025 mole) of (4-chloro-2-methylphenoxy)acetaldehyde and 2.1g (0.028 mole) of glycolamide in 25 ml of tetrahydrofuran and 25 ml of ether was allowed to stand at ambient temperature for 24 hours. The resulting product was washed with 5% sodium carbonate and water, dried and purified by silica chromatography to give 1.1g of 2-(4-chloro-2-methylphenoxymethyl)-4-oxazolidinone as a white crystalline solid melting at 109°-112°.

後処理

  1. washThe resulting product was washed with 5% sodium carbonate and water
  2. customdried
  3. custompurified by silica chromatography

出典と根拠

ORDレコード
ord-2005a2a0641041d69c36b39cd9a7f613
出典データセット
uspto-grants-1978_05
特許番号
US04090861

関連ノート

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