Methanol → 2-(1-Naphthyl)-2-(methoxycarbonyl)acetonitrile

HRID 37286

反応式

HRID 37286 の反応式
[C:1]1([CH2:11][C:12]#[N:13])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.[Na].CO.[C:17](=O)([O:20]C)[O:18][CH3:19]>>[C:1]1([CH:11]([C:17]([O:18][CH3:19])=[O:20])[C:12]#[N:13])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1

参加物

5

反応物 4

HCID 887MethanolHCID 85961-NaphthaleneacetonitrileHCID 12021Dimethyl CarbonateHCID 5360545Sodium

生成物 1

HCID 108468152-(1-Naphthyl)-2-(methoxycarbonyl)acetonitrile

実験手順

0.1 mol of 2-(1-naphthyl)acetonitrile is dissolved in 120 cm3 of dimethyl carbonate, and the solution is heated to reflux. 0.1 mol of sodium is then added in small portions over 30 min, during which time the methanol evaporates off. The reaction medium is kept refluxing for 1 hour, and the excess dimethyl carbonate is then evaporated off to dryness. The residue is taken up with 100 cm3 of an 18% solution of acetic acid in water.

後処理

  1. temperaturethe solution is heated to reflux
  2. customevaporates off
  3. temperatureThe reaction medium is kept refluxing for 1 hour
  4. customthe excess dimethyl carbonate is then evaporated off to dryness

出典と根拠

ORDレコード
ord-87392b3e925043f0acdd97a4f40532ee
出典データセット
uspto-grants-1995_05
特許番号
US05420158

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