Hydrochloric Acid → N-[2-(1-naphthyl)-2-(methoxycarbonyl)ethyl]-N'-propylurea

HRID 37288

反応式

HRID 37288 の反応式
[CH2:1]([N:4]=[C:5]=[O:6])[CH2:2][CH3:3].Cl.[C:8]1([CH:18]([C:21]([O:23][CH3:24])=[O:22])[CH2:19][NH2:20])[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH:11]=[CH:10][CH:9]=1.Cl>N1C=CC=CC=1>[C:8]1([CH:18]([C:21]([O:23][CH3:24])=[O:22])[CH2:19][NH:20][C:5]([NH:4][CH2:1][CH2:2][CH3:3])=[O:6])[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH:11]=[CH:10][CH:9]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 61033Propyl isocyanateHCID 199634602-(1-Naphthyl)-2-(methoxycarbonyl)ethylamine hydrochloride

生成物 1

HCID 19963469N-[2-(1-naphthyl)-2-(methoxycarbonyl)ethyl]-N'-propylurea

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

反応条件

温度
80 °C

実験手順

0.011 mol of propyl isocyanate is added dropwise and with magnetic stirring to a suspension of 0.01 mol of 2-(1-naphthyl)-2-(methoxycarbonyl)ethylamine hydrochloride, obtained in stage B of Example 11, in 5 cm3 of pyridine. The reaction medium is stirred for 1 hour at a temperature of 80° C. and then poured into ice-cold water. The mixture is acidified with 1N hydrochloric acid solution. The precipitate formed is drained, washed with water, dried and then recrystallized in a toluene/cyclohexane mixture.

後処理

  1. additionpoured into ice-cold water
  2. customThe precipitate formed
  3. washwashed with water
  4. customdried
  5. customrecrystallized in a toluene/cyclohexane mixture

出典と根拠

ORDレコード
ord-ad69d7ccdf8a44a18f874ef8d8f28ce9
出典データセット
uspto-grants-1995_05
特許番号
US05420158

関連ノート

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