Benzyl Chloride → N,N-Dimethyl-N-(2-benzoylaminoethyl)benzylammonium Chloride

HRID 372939

反応式

HRID 372939 の反応式
[CH3:1][N:2]([CH3:14])[CH2:3][CH2:4][NH:5][C:6](=[O:13])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[Cl:15][CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>C(#N)C>[Cl-:15].[CH3:1][N+:2]([CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)([CH3:14])[CH2:3][CH2:4][NH:5][C:6](=[O:13])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

参加物

4

反応物 2

HCID 7503Benzyl ChlorideHCID 113158N-(2-(Dimethylamino)ethyl)benzamide

生成物 1

HCID 19811098N,N-Dimethyl-N-(2-benzoylaminoethyl)benzylammonium Chloride

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

A solution of 19.23 grams (0.10 mol) of the N-(2-dimethylaminoethyl)benzamide, prepared as described in Example 1, 12.66 grams (0.10 mol) of α-chlorotoluene and 64 milliters of acetonitrile was heated at reflux for 19.75 hours. Solid crystallized on cooling which was collected, washed with acetonitrile and dried. The yield of product was 24.0 grams (75.27% of theory); mp=175°-176° C.

後処理

  1. temperaturewas heated
  2. temperatureat reflux for 19.75 hours
  3. customSolid crystallized
  4. temperatureon cooling which
  5. customwas collected
  6. washwashed with acetonitrile
  7. customdried

出典と根拠

ORDレコード
ord-80630acfb6e64d19be126317e4c1d130
出典データセット
uspto-grants-1992_11
特許番号
US05162188

関連ノート

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