Cyclohexylamine → N-cyclohexyl-2-phenylprop-2-enamide

HRID 37367

反応式

HRID 37367 の反応式
[C:1]([OH:11])(=O)[C:2]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)=[CH2:3].CN1CCOCC1.ClC(OCC(C)C)=O.[CH:27]1([NH2:33])[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]1>>[CH:27]1([NH:33][C:1](=[O:11])[C:2]([C:4]2[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=2)=[CH2:3])[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]1

参加物

5

反応物 4

HCID 7965CyclohexylamineHCID 79724-MethylmorpholineHCID 62365Isobutyl chloroformateHCID 68114Atropic acid

生成物 1

HCID 343735N-cyclohexyl-2-phenylprop-2-enamide収率 28.9%

実験手順

This compound was made from atropic acid (10.48 g, 70.8 mmol), N-methylmorpholine (7.8 ml, 70.9 mmol), iso-butyl chloroformate (9.2 ml, 70.9 mmol), and cyclohexylamine (8.1 ml, 70.7 mmol) using the procedure described in Example 3. The crude product was purified by recrystallisation from cyclohexane to give the product (4.69 g), as white crystals, m.p. 131°-133°. (Found: C, 78.7; H, 8.8; N, 5.95. C15H19NO requires C, 78.6; H, 8.35; N, 6.1%.)

後処理

  1. customThe crude product was purified by recrystallisation from cyclohexane

出典と根拠

ORDレコード
ord-5664a6be0a904b4ebe4b4d96ac6e8567
出典データセット
uspto-grants-1995_05
特許番号
US05420278

関連ノート

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