4'-Bromoacetanilide → N-(4-bromo-2-fluorophenyl)acetamide

HRID 373678

反応式

HRID 373678 の反応式
[C:1]([NH:4][C:5]1[CH:10]=[CH:9][C:8]([Br:11])=[CH:7][CH:6]=1)(=[O:3])[CH3:2].[O-]S(C(F)(F)[F:17])(=O)=O.F[N+]1C=CC=CC=1>ClC(Cl)CCl>[C:1]([NH:4][C:5]1[CH:10]=[CH:9][C:8]([Br:11])=[CH:7][C:6]=1[F:17])(=[O:3])[CH3:2]

参加物

4

反応物 2

HCID 76834'-BromoacetanilideHCID 2724576Pyridinium, 1-fluoro-, 1,1,1-trifluoromethanesulfonate (1:1)

生成物 1

HCID 67593N-(4-bromo-2-fluorophenyl)acetamide収率 28%

試薬・触媒・溶媒 1

HCID 65741,1,2-Trichloroethane溶媒

反応条件

温度
100 °C

実験手順

A mixture of 1.17 g (5.0 mmol) of N-acetyl-4-bromoaniline, 1.20 g (5.0 mmol) of N-fluoropyridinium triflate, and 50 ml of 1,1,2-trichloroethane was placed in a 100 ml 3-necked round bottomed flask equipped with a magnetic stirring bar, a thermometer, and a reflux condenser. The mixture was heated to 100° C. and allowed to react at that temperature for 20 hours. The mixture was then allowed to cool and the volatiles were removed by evaporation under reduced pressure. Analysis of the residue by standardized gas-liquid chromatography using a mass spectrometer detector indicated that the title product was present in 28 percent yield and that the balance of the N-acetyl-4-bromoaniline was still present as unreacted material.

後処理

  1. customwas placed in a 100 ml 3-necked round bottomed flask
  2. customequipped with a magnetic stirring bar
  3. customto react at that temperature for 20 hours
  4. temperatureto cool
  5. customthe volatiles were removed by evaporation under reduced pressure

出典と根拠

ORDレコード
ord-9c2faacbfe2e4ec3bac22144d3f63261
出典データセット
uspto-grants-1992_11
特許番号
US05164502

関連ノート

読み込み中…